Sequence identification of cytochrome b in Plasmodium gallinaceum

Mol Cell Biol. 1989 Sep;9(9):3614-20. doi: 10.1128/mcb.9.9.3614-3620.1989.


We have identified a gene that encodes the polypeptide cytochrome b in the avian malarial parasite Plasmodium gallinaceum. The gene containing the open reading frame was found to be located on a 6.2-kilobase multimeric extrachromosomal element. The amino acid translation from this gene demonstrated significant similarities to cytochrome b sequences from yeast, mammal, and fungus genomes. We present evidence that the P. gallinaceum cytochrome b transcript is part of a larger primary transcript from the element that is subsequently processed. The message for P. gallinaceum cytochrome b was found to be 1.2 kilobases in size. This is the first report identifying a mitochondrial nucleic acid sequence in malaria-causing organisms and suggests that a functional cytochrome system may exist in these parasites.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Cytochrome b Group / genetics*
  • DNA / genetics
  • Molecular Sequence Data
  • Plasmodium / genetics*
  • Plasmodium gallinaceum / genetics*
  • Restriction Mapping
  • Sequence Homology, Nucleic Acid
  • Transcription, Genetic


  • Cytochrome b Group
  • DNA