Intravoxel incoherent motion (IVIM)-derived parameters in diffusion-weighted MRI: Associations with prognostic factors in invasive ductal carcinoma

J Magn Reson Imaging. 2017 May;45(5):1394-1406. doi: 10.1002/jmri.25514. Epub 2016 Oct 31.


Purpose: To investigate relationships between intravoxel incoherent motion (IVIM) metrics of invasive ductal carcinoma of the breast and prognostic factors.

Materials and methods: This retrospective study included a total of 82 masses from 72 patients who underwent 3T breast magnetic resonance imaging (MRI) and diffusion-weighted imaging. IVIM metrics of tissue diffusivity (Dslow ), pseudodiffusivity (Dfast ), and perfusion fraction (Dpf ) were measured using histogram analysis for whole lesion volumes. We evaluated relationships between IVIM metrics and prognostic factors or subtypes of invasive ductal carcinoma.

Results: The Dslow 50th , 75th , and 90th percentile metrics were reduced in the estrogen receptor (ER)-positive group compared with the ER-negative group (individually, P = 0.044, 0.024, 0.045). Additionally, the Dslow 75th percentile value was a significant differentiator of histologic grade, tumor subtype, and Ki-67 grouping (individually, P = 0.024, 0.049, 0.016). The Dpf mean, 75th , 90th percentile, skewness, and kurtosis metrics were correlated with the size of ductal carcinoma in situ (DCIS) component (individually, P = 0.034, 0.032, 0.027, 0.013, 0.013).

Conclusion: The Dslow metrics differentiated between ER-positive and -negative groups, and the Dpf metrics were associated with the size of the DCIS component.

Level of evidence: 4 J. MAGN. RESON. IMAGING 2017;45:1394-1406.

Keywords: diffusion weighted image; intravoxel incoherent motion; invasive ductal carcinoma; magnetic resonance imaging; prognostic factor.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Biopsy
  • Breast / diagnostic imaging
  • Breast Neoplasms / diagnostic imaging*
  • Breast Neoplasms / pathology
  • Carcinoma, Ductal, Breast / diagnostic imaging*
  • Carcinoma, Ductal, Breast / pathology
  • Diffusion Magnetic Resonance Imaging*
  • Female
  • Humans
  • Image Processing, Computer-Assisted / methods*
  • Middle Aged
  • Motion
  • Perfusion
  • Prognosis
  • Retrospective Studies