Clin Rheumatol. 2017 Jan;36(1):9-14. doi: 10.1007/s10067-016-3459-7. Epub 2016 Oct 29.


Acro-osteolysis is an osteolysis of the distal phalanges of the hands and feet and can affect the terminal tuft or the shaft of the distal phalanx (transverse or band acro-osteolysis). It is often associated with distal digital ischemia, digital calcinosis, or severe sensory neuropathy. Acro-osteolysis has been associated with a heterogeneous group of disorders, including occupational activities, infections, rheumatic disorders (systemic sclerosis, psoriatic arthritis), endocrinopathies, genetic disorders, and lysosomal storage disorders. Plain radiography is the gold standard for the detection of acro-osteolysis.

Keywords: Digital ischemia; Infection; Psoriatic arthritis; Systemic sclerosis; Transverse acro-osteolysis.

Publication types

  • Review

MeSH terms

  • Acro-Osteolysis / diagnostic imaging
  • Finger Phalanges / diagnostic imaging
  • Fingers / diagnostic imaging
  • Hajdu-Cheney Syndrome / diagnostic imaging
  • Hand / diagnostic imaging
  • Humans
  • Hyperparathyroidism / diagnostic imaging
  • Ischemia / diagnostic imaging
  • Leprosy / diagnostic imaging
  • Leprosy / genetics
  • Lysosomal Storage Diseases / diagnostic imaging
  • Mutation
  • Osteolysis / diagnostic imaging*
  • Rheumatic Diseases / diagnostic imaging
  • Rheumatology / methods*
  • Scleroderma, Systemic / diagnostic imaging