Developing a paediatric drug formulary for the Netherlands

Arch Dis Child. 2017 Apr;102(4):357-361. doi: 10.1136/archdischild-2016-311674. Epub 2016 Oct 31.


As many drugs in paediatrics are used off-label, prescribers face a lack of evidence-based dosing guidelines. A Dutch framework was developed to provide dosing guidelines based on best available evidence from registration data, investigator-initiated research, professional guidelines, clinical experience and consensus. This has clarified the scientific grounds of drug use for children and encouraged uniformity in prescribing habits in the Netherlands. The developed framework and the current content of the Dutch Paediatric Formulary could be used as basis for similar initiatives worldwide, preferably in a concerted effort to ultimately provide children with effective and safe drug therapy.

Keywords: Evidence Based Medicine; Pharmacology; Therapeutics.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Child
  • Consensus
  • Drug Administration Schedule
  • Drug Approval
  • Evidence-Based Medicine
  • Formularies as Topic*
  • Humans
  • Knowledge Bases
  • Netherlands
  • Off-Label Use