A retrospective review of 242 consecutive dacryocystorhinostomies (DCRs) revealed no association between failure and either age, gender, or etiology of the nasolacrimal obstruction. However, silicone intubation of the nasolacrimal system was associated with a statistically significant increase in the failure rate of primary DCR. We postulate that silicone tubing by inciting granuloma formation in the nose and lacrimal fossa, predisposes to DCR failure. Routine use of silicone tubing in DCR should be avoided unless there is canalicular scarring, a large valve of Rosenmueller occluding the common canaliculus, or a small contracted or scarred lacrimal sac.