[The significance of peripheral blood natural killer cell surface CD107a, NKG2D and serum sMICA in patients with extranodal NK/T cell lymphoma, nasal type]

J X Liu; J W Wang; X Y Cui

doi:10.3760/cma.j.issn.0578-1426.2016.11.012

[The significance of peripheral blood natural killer cell surface CD_107a, NKG2D and serum sMICA in patients with extranodal NK/T cell lymphoma, nasal type]

Zhonghua Nei Ke Za Zhi. 2016 Nov 1;55(11):872-874. doi: 10.3760/cma.j.issn.0578-1426.2016.11.012.

[Article in Chinese]

Authors

J X Liu¹, J W Wang, X Y Cui

Affiliation

¹ Department of Hematology, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China.

PMID: 27801344
DOI: 10.3760/cma.j.issn.0578-1426.2016.11.012

Abstract

The expression of CD_107a, NKG2D on the surface of natural killer (NK) cells and serum soluble major histocompatibility complex class Ⅰ chain-related A (sMICA) level in patients with extranodal NK/T cell lymphoma, nasal type (ENKL) were detected.We found that CD_107a expression was reduced on the surface of NK cells, suggesting impaired NK cell activity in ENKL patients, which may result from decreased NKG2D expression.

MeSH terms

Histocompatibility Antigens Class I / blood*
Histocompatibility Antigens Class I / metabolism
Humans
Killer Cells, Natural / immunology*
Killer Cells, Natural / metabolism*
Lymphoma, Extranodal NK-T-Cell / blood
Lymphoma, Extranodal NK-T-Cell / immunology*
Lymphoma, Extranodal NK-T-Cell / pathology
NK Cell Lectin-Like Receptor Subfamily K / metabolism*
Nose Neoplasms / blood
Nose Neoplasms / immunology*
Nose Neoplasms / pathology

Substances

Histocompatibility Antigens Class I
KLRK1 protein, human
MHC class I-related chain A
NK Cell Lectin-Like Receptor Subfamily K