A Clinical Trial about a Food Supplement Containing α-Lipoic Acid on Oxidative Stress Markers in Type 2 Diabetic Patients

Int J Mol Sci. 2016 Oct 28;17(11):1802. doi: 10.3390/ijms17111802.

Abstract

The aim of this study was to evaluate the effect of a food supplement containing α-lipoic acid and of a placebo on glyco-metabolic control and on oxidative stress markers in type 2 diabetics. We randomized 105 diabetics to either a supplementation containing 600 mg of α-lipoic acid, 165 mg of L-carnosin, 7.5 mg of zinc, and vitamins of group B, or a placebo, for three months. We evaluated body mass index, fasting plasma glucose (FPG), post-prandial-glucose (PPG), glycated hemoglobin (HbA1c), fasting plasma insulin (FPI), HOMA-index (HOMA-IR), lipid profile, high sensitivity C-reactive protein (Hs-CRP), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), malondialdehyde (MDA). There was a reduction of FPG, PPG, and HbA1c with the food supplement containing α-lipoic acid compared with a baseline, and with the placebo. Concerning lipid profile, we observed a reduction of LDL-C, and Tg with the food supplement, compared with both the baseline, and the placebo. There was a reduction of Hs-CRP with the food supplement containing α-lipoic acid, both compared with the baseline and the placebo. An increase of SOD, and GSH-Px, and a decrease of MDA were reached by the food supplement containing α-lipoic acid, both compared with the baseline and the placebo. We can conclude that the food supplement containing α-lipoic acid, L-carnosin, zinc, and vitamins of group B improved glycemic control, lipid profile, and anti-oxidative stress markers.

Keywords: L-carnosin; malondialdehyde; oxidative stress; α-lipoic acid.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Biomarkers / blood
  • Blood Glucose
  • Body Mass Index
  • Body Weight
  • C-Reactive Protein / metabolism
  • Carnosine / administration & dosage
  • Diabetes Mellitus, Type 2 / blood*
  • Diabetes Mellitus, Type 2 / diet therapy
  • Diabetes Mellitus, Type 2 / pathology
  • Dietary Supplements*
  • Female
  • Glutathione Peroxidase / blood
  • Glycated Hemoglobin A / metabolism
  • Humans
  • Inflammation / blood
  • Inflammation / diet therapy*
  • Inflammation / pathology
  • Insulin Resistance / genetics
  • Lipid Metabolism / drug effects
  • Male
  • Middle Aged
  • Oxidative Stress / drug effects*
  • Thioctic Acid / administration & dosage
  • Zinc / administration & dosage

Substances

  • Biomarkers
  • Blood Glucose
  • Glycated Hemoglobin A
  • hemoglobin A1c protein, human
  • Thioctic Acid
  • Carnosine
  • C-Reactive Protein
  • Glutathione Peroxidase
  • Zinc