Two Cases of Acute Disseminated Encephalomyelitis Following Vaccination Against Human Papilloma Virus

Intern Med. 2016;55(21):3181-3184. doi: 10.2169/internalmedicine.55.5472. Epub 2016 Nov 1.

Abstract

We herein present two cases of acute disseminated encephalomyelitis (ADEM) following vaccination against human papilloma virus (HPV). Case 1 experienced diplopia and developed an unstable gait 14 days after a second vaccination of Cervarix. Brain magnetic resonance imaging (MRI) showed an isolated small, demyelinating lesion in the pontine tegmentum. Case 2 experienced a fever and limb dysesthesia 16 days after a second vaccination of Gardasil. Brain MRI revealed hyperintense lesion in the pons with slight edema on a T2-weighted image. Both cases resolved completely. It is important to accumulate further data on confirmed cases of ADEM temporally associated with HPV vaccination.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Diagnosis, Differential
  • Encephalomyelitis, Acute Disseminated / diagnosis*
  • Encephalomyelitis, Acute Disseminated / diagnostic imaging
  • Encephalomyelitis, Acute Disseminated / etiology
  • Female
  • Humans
  • Magnetic Resonance Imaging
  • Papillomaviridae / immunology*
  • Papillomavirus Vaccines / adverse effects*
  • Vaccination / adverse effects

Substances

  • Papillomavirus Vaccines
  • human papillomavirus vaccine, L1 type 16, 18