Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1989 Sep;86(18):7049-53.
doi: 10.1073/pnas.86.18.7049.

Conservation of the Human Telomere Sequence (TTAGGG)n Among Vertebrates

Affiliations
Free PMC article

Conservation of the Human Telomere Sequence (TTAGGG)n Among Vertebrates

J Meyne et al. Proc Natl Acad Sci U S A. .
Free PMC article

Abstract

To determine the evolutionary origin of the human telomere sequence (TTAGGG)n, biotinylated oligodeoxynucleotides of this sequence were hybridized to metaphase spreads from 91 different species, including representative orders of bony fish, reptiles, amphibians, birds, and mammals. Under stringent hybridization conditions, fluorescent signals were detected at the telomeres of all chromosomes, in all 91 species. The conservation of the (TTAGGG)n sequence and its telomeric location, in species thought to share a common ancestor over 400 million years ago, strongly suggest that this sequence is the functional vertebrate telomere.

Similar articles

See all similar articles

Cited by 216 articles

See all "Cited by" articles

References

    1. Biochemistry. 1974 Sep 10;13(19):3930-7 - PubMed
    1. Proc Natl Acad Sci U S A. 1989 Aug;86(16):6240-4 - PubMed
    1. J Mol Biol. 1978 Mar 25;120(1):33-53 - PubMed
    1. Nucleic Acids Res. 1980 Aug 25;8(16):3695-707 - PubMed
    1. Cell. 1980 Dec;22(3):875-86 - PubMed

Publication types

LinkOut - more resources

Feedback