Chorea and parkinsonism associated with autoantibodies to IgLON5 and responsive to immunotherapy

J Neuroimmunol. 2016 Nov 15;300:9-10. doi: 10.1016/j.jneuroim.2016.09.012. Epub 2016 Sep 24.

Abstract

Encephalopathy associated with autoantibodies to IgLON5 is a novel syndrome characterized by a distinct sleep disorder and brain-stem involvement. Since the initial description of this encephalopathy in 2014, only a few additional patients have been reported (Simabukuro et al., 2015). In this paper, we report a new case of anti-IgLON5 antibodies with major symptoms of chorea and parkinsonism, and responsive to immunotherapy.

Publication types

  • Case Reports

MeSH terms

  • Autoantibodies / blood*
  • Cell Adhesion Molecules, Neuronal / blood*
  • Chorea / blood*
  • Chorea / diagnosis
  • Chorea / drug therapy
  • Female
  • Humans
  • Immunoglobulins, Intravenous / administration & dosage*
  • Immunotherapy / methods*
  • Middle Aged
  • Parkinsonian Disorders / blood*
  • Parkinsonian Disorders / diagnosis
  • Parkinsonian Disorders / drug therapy

Substances

  • Autoantibodies
  • Cell Adhesion Molecules, Neuronal
  • IgLON5 protein, human
  • Immunoglobulins, Intravenous