Quality of life and related factors among chronic hepatitis B-infected patients: a multi-center study, Turkey

Health Qual Life Outcomes. 2016 Nov 3;14(1):153. doi: 10.1186/s12955-016-0557-9.


Background: The aim of this study was to assess health-related quality of life (HRQOL) among chronic hepatitis B (CHB) patients in Turkey and to study related factors.

Methods: This multicenter study was carried out between January 01 and April 15, 2015 in Turkey in 57 centers. Adults were enrolled and studied in three groups. Group 1: Inactive HBsAg carriers, Group 2: CHB patients receiving antiviral therapy, Group 3: CHB patients who were neither receiving antiviral therapy nor were inactive HBsAg carriers. Study data was collected by face-to-face interviews using a standardized questionnaire, Short Form-36 (SF-36) and Hepatitis B Quality of Life (HBQOL). Values equivalent to p < 0.05 in analyses were accepted as statistically significant.

Results: Four thousand two hundred fifty-seven patients with CHB were included in the study. Two thousand five hundred fifty-nine (60.1 %) of the patients were males. Groups 1, 2 and 3, consisted of 1529 (35.9 %), 1721 (40.4 %) and 1007 (23.7 %) patients, respectively. The highest value of HRQOL was found in inactive HBsAg carriers. We found that total HBQOL score increased when antiviral treatment was used. However, HRQOL of CHB patients varied according to their socio-demographic properties. Regarding total HBQOL score, a higher significant level of HRQOL was determined in inactive HBV patients when matched controls with the associated factors were provided.

Conclusions: The HRQOL score of CHB patients was higher than expected and it can be worsen when the disease becomes active. Use of an antiviral therapy can contribute to increasing HRQOL of patients.

Keywords: Chronic hepatitis B infection; Quality of life; The Hepatitis B Quality of Life Instrument; Turkey.

Publication types

  • Clinical Trial
  • Multicenter Study

MeSH terms

  • Adult
  • Aged
  • Antiviral Agents / therapeutic use
  • Cross-Sectional Studies
  • Female
  • Health Status Indicators
  • Hepatitis B, Chronic* / drug therapy
  • Hepatitis B, Chronic* / psychology
  • Humans
  • Interviews as Topic
  • Male
  • Middle Aged
  • Prospective Studies
  • Quality of Life*
  • Turkey


  • Antiviral Agents