The emerging role of long non-coding RNAs in endometrial cancer

Konii Takenaka; Bei Jun Chen; Susan C Modesitt; Frances L Byrne; Kyle L Hoehn; Michael Janitz

doi:10.1016/j.cancergen.2016.09.005

The emerging role of long non-coding RNAs in endometrial cancer

Cancer Genet. 2016 Oct;209(10):445-455. doi: 10.1016/j.cancergen.2016.09.005. Epub 2016 Sep 13.

Authors

Konii Takenaka¹, Bei Jun Chen¹, Susan C Modesitt², Frances L Byrne¹, Kyle L Hoehn¹, Michael Janitz³

Affiliations

¹ School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW 2052, Australia.
² Division of Gynecologic Oncology, Obstetrics and Gynecology Department, University of Virginia Health System, Charlottesville, VA 22908, USA.
³ School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW 2052, Australia. Electronic address: m.janitz@unsw.edu.au.

PMID: 27810073
DOI: 10.1016/j.cancergen.2016.09.005

Abstract

The human genome is pervasively transcribed and approximately 98% of the genome is non-coding. Long non-coding RNAs (lncRNAs) are a heterogeneous group of RNA transcripts that are >200 nucleotides in length with minimal to no protein-coding potential. Similar to proteins, lncRNAs have important biological functions in both normal cells and disease states including many types of cancer. This review summarizes recent advances in our understanding of lncRNAs in cancer biology and highlights the potential for lncRNA as diagnostic biomarkers and therapeutics. Herein we focus on the poorly understood role of lncRNAs in endometrial cancer, the most common gynecologic malignancy in the developed world.

Keywords: Endometrial cancer; gene expression; lincRNAs; long non-coding RNAs; transcriptome.

Publication types

Review

MeSH terms

Endometrial Neoplasms / genetics*
Female
Humans
RNA, Long Noncoding / genetics*

Substances

RNA, Long Noncoding