Impact of HIF-1α and hypoxia on fungal growth characteristics and fungal immunity

Microbes Infect. 2017 Mar;19(3):204-209. doi: 10.1016/j.micinf.2016.10.008. Epub 2016 Oct 31.

Abstract

Human pathogenic fungi are highly adaptable to a changing environment. The ability to adjust to low oxygen conditions is crucial for colonization and infection of the host. Recently, the impact of mammalian hypoxia-inducible factor-1α (HIF-1α) on fungal immunity has emerged. In this review, the role of hypoxia and HIF-1α in fungal infections is discussed regarding the innate immune response.

Keywords: Fungal immunity; HIF-1; Hypoxia; SREBP.

Publication types

  • Review

MeSH terms

  • Animals
  • Disease Models, Animal
  • Fungi / growth & development
  • Fungi / immunology*
  • Fungi / pathogenicity*
  • Humans
  • Hypoxia / pathology*
  • Hypoxia-Inducible Factor 1, alpha Subunit / metabolism*
  • Immunity, Innate*
  • Mycoses / immunology*
  • Mycoses / pathology*

Substances

  • Hypoxia-Inducible Factor 1, alpha Subunit