[Comparative studies of diatrizoate, ioxaglate and iohexol as angiocardiographic contrast media]

Rev Esp Cardiol. 1989 Mar;42(3):173-6.
[Article in Spanish]


We did 2 consecutive randomized studies to compare the effects of diatrizoate, ioxaglate, and iohexol. Sixty patients were studied: 15 with diatrizoate (group I) versus 15 with ioxaglate (IIA), and 15 with ioxaglate (IIB) versus 15 with iohexol (III). Group I had hypotension and severe increase in end-diastolic pressure. Severe bradycardia was seen in 27% of the cases. Group IIA and IIB had identical changes, with a moderate increase in systolic and end-diastolic pressure. Group III only presented a mild increase in end-diastolic pressure. None of the low-osmolar contrast media produced severe bradycardia, but ioxaglate induced frequent (20%) nausea. Our results suggest the best contrast media for angiocardiography is, in decreasing order: iohexol, ioxaglate, and diatrizoate.

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Angiocardiography
  • Bradycardia / chemically induced
  • Coronary Disease / diagnostic imaging*
  • Diatrizoate / adverse effects*
  • Female
  • Humans
  • Hypotension / chemically induced
  • Iohexol / adverse effects*
  • Ioxaglic Acid / adverse effects*
  • Male
  • Middle Aged
  • Random Allocation


  • Diatrizoate
  • Iohexol
  • Ioxaglic Acid