The Humanistic Burden of Type 1 Diabetes Mellitus in Europe: Examining Health Outcomes and the Role of Complications

PLoS One. 2016 Nov 3;11(11):e0164977. doi: 10.1371/journal.pone.0164977. eCollection 2016.

Abstract

Aims: Diagnoses of Type 1 Diabetes Mellitus (T1DM) in Europe appear to be on the rise. Therefore it is imperative that researchers understand the potential impact that increases in prevalence could have on the affected individuals as well as on society as a whole. Accordingly this study examined the humanistic and economic burden of T1DM in patients relative to those without the condition across a number of health outcomes including health status, work productivity loss, activity impairment, and healthcare resource use.

Methods: Survey data from a large, representative sample of EU adults (The EU National Health and Wellness Survey) were examined.

Results: Results suggest that overall burden is higher for those diagnosed with T1DM than respondents without diabetes and that burden increases as complications associated with T1DM increase.

Conclusions: Taken together, these results suggest that treatment strategies for T1DM should balance clinical, humanistic, and economic burden and patients should be educated on the role of complications in disease outcomes.

MeSH terms

  • Adolescent
  • Adult
  • Cost of Illness
  • Diabetes Mellitus, Type 1 / complications*
  • Diabetes Mellitus, Type 1 / economics
  • Diabetes Mellitus, Type 1 / epidemiology*
  • Europe / epidemiology
  • Female
  • Health Resources / statistics & numerical data
  • Health Surveys*
  • Humans
  • Male
  • Middle Aged
  • Young Adult

Grants and funding

This work was funded by AstraZeneca, a commercial company. AstraZeneca provided additional support in the form of salaries for authors AR, ES, KB, AR, FT, and CS. Kantar Health, a commercial company, provided support in the form of salary for author EW. These funders did not have any additional role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript. The specific roles of these authors are articulated in the 'author contributions' section.