Haploid Human Embryonic Stem Cells: Half the Genome, Double the Value

Cell Stem Cell. 2016 Nov 3;19(5):569-572. doi: 10.1016/j.stem.2016.10.009.


Recent advances in the generation of haploid embryonic stem cells (ESCs), capable of self-renewal and differentiation, have laid the groundwork for numerous biomedical applications in developmental biology and reproductive medicine. When combined with the power of genetic screening, haploid human ESCs could advance cancer research, regenerative medicine, and disease modeling.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Genetic Testing
  • Genome, Human*
  • Haploidy*
  • Human Embryonic Stem Cells / metabolism*
  • Humans
  • Models, Biological
  • Reproductive Medicine