Haploid Human Embryonic Stem Cells: Half the Genome, Double the Value

Atilgan Yilmaz; Mordecai Peretz; Ido Sagi; Nissim Benvenisty

doi:10.1016/j.stem.2016.10.009

Haploid Human Embryonic Stem Cells: Half the Genome, Double the Value

Cell Stem Cell. 2016 Nov 3;19(5):569-572. doi: 10.1016/j.stem.2016.10.009.

Authors

Atilgan Yilmaz¹, Mordecai Peretz¹, Ido Sagi², Nissim Benvenisty³

Affiliations

¹ The Azrieli Center for Stem Cells and Genetic Research, Department of Genetics, Silberman Institute of Life Sciences, The Hebrew University, Jerusalem 91904, Israel.
² The Azrieli Center for Stem Cells and Genetic Research, Department of Genetics, Silberman Institute of Life Sciences, The Hebrew University, Jerusalem 91904, Israel. Electronic address: ido.sagi@mail.huji.ac.il.
³ The Azrieli Center for Stem Cells and Genetic Research, Department of Genetics, Silberman Institute of Life Sciences, The Hebrew University, Jerusalem 91904, Israel. Electronic address: nissimb@mail.huji.ac.il.

PMID: 27814478
DOI: 10.1016/j.stem.2016.10.009

Abstract

Recent advances in the generation of haploid embryonic stem cells (ESCs), capable of self-renewal and differentiation, have laid the groundwork for numerous biomedical applications in developmental biology and reproductive medicine. When combined with the power of genetic screening, haploid human ESCs could advance cancer research, regenerative medicine, and disease modeling.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Genetic Testing
Genome, Human*
Haploidy*
Human Embryonic Stem Cells / metabolism*
Humans
Models, Biological
Reproductive Medicine