Did a Single Amino Acid Change Make Ebola Virus More Virulent?

Cell. 2016 Nov 3;167(4):892-894. doi: 10.1016/j.cell.2016.10.032.


A mutation in the Ebola virus glycoprotein arose early during the 2013-2016 epidemic and dominated the viral population. Two studies by Diehl et al. and Urbanowicz et al. now reveal that this mutation is associated with higher infectivity to human cells, representing the clearest example of Ebola's functional adaptation to human hosts.

Publication types

  • Comment

MeSH terms

  • Amino Acids / genetics
  • Ebolavirus / genetics*
  • Glycoproteins / genetics
  • Hemorrhagic Fever, Ebola / epidemiology*
  • Humans
  • Mutation


  • Amino Acids
  • Glycoproteins