The dementia-associated APOE ε4 allele is not associated with rapid eye movement sleep behavior disorder

Neurobiol Aging. 2017 Jan;49:218.e13-218.e15. doi: 10.1016/j.neurobiolaging.2016.10.002. Epub 2016 Oct 13.


The present study aimed to examine whether the APOE ε4 allele, associated with dementia with Lewy bodies (DLB), and possibly with dementia in Parkinson's disease (PD), is also associated with idiopathic rapid eye movement sleep behavior disorder (RBD). Two single nucleotide polymorphisms, rs429358 and rs7412, were genotyped in RBD patients (n = 480) and in controls (n = 823). APOE ε4 allele frequency was 0.14 among RBD patients and 0.13 among controls (OR = 1.11, 95% CI: 0.88-1.40, p = 0.41). APOE ε4 allele frequencies were similar in those who converted to DLB (0.14) and those who converted to Parkinson's disease (0.12) or multiple system atrophy (0.14, p = 1.0). The APOE ε4 allele is neither a risk factor for RBD nor it is associated with conversion from RBD to DLB or other synucleinopathies.

Keywords: APOE; Dementia with Lewy bodies; Genetics; Parkinson's disease; REM sleep behavior disorder.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Alleles*
  • Apolipoproteins E / genetics*
  • Female
  • Gene Frequency
  • Genetic Association Studies*
  • Humans
  • Lewy Body Disease / genetics*
  • Male
  • Multiple System Atrophy / genetics
  • Parkinson Disease / genetics
  • Polymorphism, Single Nucleotide*
  • REM Sleep Behavior Disorder / genetics*
  • Risk Factors
  • Supranuclear Palsy, Progressive / genetics
  • Young Adult


  • Apolipoproteins E

Supplementary concepts

  • Progressive supranuclear palsy atypical