Development of a Risk Prediction Score for Occult Cancer in Patients With VTE

Chest. 2017 Mar;151(3):564-571. doi: 10.1016/j.chest.2016.10.025. Epub 2016 Nov 1.


Background: The benefits of a diagnostic workup for occult cancer in patients with VTE are controversial. Our aim was to provide and validate a risk score for occult cancer in patients with VTE.

Methods: We designed a nested case-control study in a cohort of patients with VTE included in the RIETE (Registro Informatizado Enfermedad TromboEmbólica) registry from 2001 to 2014. Cases included cancer detected beyond the first 30 days and up to 24 months after VTE. Control subjects were defined as patients with VTE with no cancer in the same period.

Results: Of 5,863 eligible patients, 444 (7.6%; 95% CI, 6.8%-8.2%) were diagnosed with occult cancer. On multivariable analysis, variables selected were male sex, age > 70 years, chronic lung disease, anemia, elevated platelet count, prior VTE, and recent surgery. We built a risk score assigning points to each variable. Internal validity was confirmed using bootstrap analysis. The proportion of patients with cancer who scored ≤ 2 points was 5.8% (241 of 4,150) and that proportion in those who scored ≥ 3 points was 12% (203 of 1,713). We also identified scores divided by sex and age subgroups.

Conclusions: This is the first risk score that has identified patients with VTE who are at increased risk for occult cancer. Our score needs to be externally validated.

Keywords: neoplasm; pulmonary embolism; risk; screening; venous thromboembolism.

Publication types

  • Observational Study

MeSH terms

  • Age Factors
  • Aged
  • Aged, 80 and over
  • Anemia / epidemiology
  • Case-Control Studies
  • Female
  • Humans
  • Lung Diseases / epidemiology
  • Male
  • Middle Aged
  • Multivariate Analysis
  • Neoplasms / diagnosis
  • Neoplasms / epidemiology*
  • Pulmonary Embolism / epidemiology*
  • Registries*
  • Reproducibility of Results
  • Risk Assessment
  • Sex Factors
  • Spain / epidemiology
  • Surgical Procedures, Operative / statistics & numerical data
  • Thrombocytosis / epidemiology
  • Venous Thromboembolism / epidemiology
  • Venous Thrombosis / epidemiology*