Hypertension Is a Risk Factor for Several Types of Heart Disease: Review of Prospective Studies

Adv Exp Med Biol. 2017;956:419-426. doi: 10.1007/5584_2016_99.


Many prospective cohort studies have demonstrated that hypertension is a strong risk factor for total mortality and cardiovascular disease (CVD). Heart disease includes coronary heart disease (CHD), heart failure, atrial fibrillation, valvular disease, sudden cardiac death (SCD), sick sinus syndrome (SSS), cardiomyopathy, and aortic aneurysms. Most of the epidemiologic prospective studies of heart disease focused on coronary/ischemic heart disease. Here we comprehensively reviewed the association between hypertension and the above-mentioned heart diseases. We found that CHD, heart failure, atrial fibrillation, aortic valvular disease, SCD, SSS, left ventricular hypertrophy, and abdominal aortic aneurysms were all associated with hypertension. Those relations tended to be stronger in men. The prevention of hypertension and lowering one's blood pressure may help reduce the risk of developing heart disease.

Keywords: Epidemiology; Heart disease; Hypertension; Prospective studies; Risk factors.

Publication types

  • Research Support, N.I.H., Intramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Blood Pressure*
  • Female
  • Heart Diseases / etiology*
  • Heart Diseases / mortality
  • Heart Diseases / physiopathology
  • Humans
  • Hypertension / complications*
  • Hypertension / mortality
  • Hypertension / physiopathology
  • Male
  • Prognosis
  • Prospective Studies
  • Risk Factors
  • Sex Factors