Abstract
49 infants and children with acute diarrhea with mild to moderate dehydration have been rehydrated orally with a newly composed oral rehydration solution. This solution differs from the traditional WHO recommended rehydration solution in a lower sodium content of 60 mval/l and replacement of bicarbonate 25 mval/l by an equimolar amount of citrate. The taste of the solution was improved by addition of flavour. All infants and children - including 8 infants less than 3 months of age - were successfully rehydrated. The solution was well accepted; no side effects have been observed. The sodium content remained normal in all patients.
MeSH terms
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Bicarbonates / administration & dosage*
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Body Weight / drug effects
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Child, Preschool
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Citrates / administration & dosage
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Citric Acid
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Diarrhea, Infantile / therapy*
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Dose-Response Relationship, Drug
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Fluid Therapy / methods*
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Glucose / administration & dosage*
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Glucose Solution, Hypertonic / administration & dosage
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Humans
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Infant
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Potassium Chloride / administration & dosage*
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Sodium Chloride / administration & dosage*
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Water-Electrolyte Balance / drug effects
Substances
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Bicarbonates
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Citrates
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Glucose Solution, Hypertonic
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World Health Organization oral rehydration solution
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Citric Acid
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Sodium Chloride
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Potassium Chloride
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Glucose