The age factor in axonal repair after spinal cord injury: A focus on neuron-intrinsic mechanisms

Neurosci Lett. 2017 Jun 23;652:41-49. doi: 10.1016/j.neulet.2016.11.003. Epub 2016 Nov 3.


Age is an important consideration for recovery and repair after spinal cord injury. Spinal cord injury is increasingly affecting the middle-aged and aging populations. Despite rapid progress in research to promote axonal regeneration and repair, our understanding of how age can modulate this repair is rather limited. In this review, we discuss the literature supporting the notion of an age-dependent decline in axonal growth after central nervous system (CNS) injury. While both neuron-intrinsic and extrinsic factors are involved in the control of axon growth after injury, here we focus on possible intrinsic mechanisms for this age-dependent decline.

Keywords: Aging; Axon growth; Axon regeneration; CNS injury; Neuron-intrinsic; Spinal cord injury.

Publication types

  • Review

MeSH terms

  • Age Factors
  • Animals
  • Axons / pathology
  • Neurons / metabolism
  • Neurons / pathology*
  • Pyramidal Tracts / pathology
  • Signal Transduction
  • Spinal Cord / pathology*
  • Spinal Cord / physiopathology
  • Spinal Cord Injuries / pathology*
  • Spinal Cord Injuries / physiopathology
  • Spinal Cord Injuries / therapy
  • Spinal Cord Regeneration