CHARMM36m: an improved force field for folded and intrinsically disordered proteins

Nat Methods. 2017 Jan;14(1):71-73. doi: 10.1038/nmeth.4067. Epub 2016 Nov 7.


The all-atom additive CHARMM36 protein force field is widely used in molecular modeling and simulations. We present its refinement, CHARMM36m (, with improved accuracy in generating polypeptide backbone conformational ensembles for intrinsically disordered peptides and proteins.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, N.I.H., Extramural

MeSH terms

  • Humans
  • Hydrogen Bonding
  • Hydrophobic and Hydrophilic Interactions
  • Intrinsically Disordered Proteins / chemistry*
  • Molecular Dynamics Simulation*
  • Protein Conformation
  • Protein Folding*


  • Intrinsically Disordered Proteins