Does preoperative neutrophil to lymphocyte or platelet to lymphocyte ratios have a role in predicting borderline ovarian tumors?

J Ovarian Res. 2016 Nov 8;9(1):78. doi: 10.1186/s13048-016-0283-2.


Background: to investigate the value of using preoperative neutrophil to lymphocyte and platelet to lymphocyte levels in the patients of borderline ovarian tumors.

Methods: During the period between January 2002 and December 2015, the pathology reports and archival files of the Gynecologic Oncology Department of Çukurova University Medical Hospital and the Gynecologic Oncology Department of Dumlupınar University, Evliya Çelebi Education and Research Hospital were retrospectively reviewed, and 144 patients of borderline ovarian tumor (as the study group) and 123 patients of serous cystadenoma (as the control group) were determined for eligibility in this study. Data regarding age, menopausal status, preoperative ultrasound findings, ca125 and complete blood counts were reviewed. Neutrophil to lymphocyte and platelet to lymphocyte ratios were calculated and these parameters were statistically compared between the groups.

Results: There was a statistically significant difference between the groups according to neutrophil count, platelet count, neutrophil to lymphocyte ratio and platelet to lymphocyte ratio; in addition to age, ca125 and preoperative ultrasound findings.

Conclusions: It seems that neutrophil to lymphocyte and platelet to lymphocyte ratios are useful in predicting borderline ovarian tumors, preoperatively. However, further prospective studies are needed.

Keywords: Borderline ovarian tumors; Neutrophil to lymphocyte ratio; Platelet to lymphocyte ratio.

Publication types

  • Comparative Study

MeSH terms

  • Adult
  • Aged
  • CA-125 Antigen / metabolism
  • Cystadenoma, Serous / blood*
  • Cystadenoma, Serous / diagnostic imaging*
  • Cystadenoma, Serous / metabolism
  • Female
  • Humans
  • Leukocyte Count
  • Lymphocyte Count
  • Membrane Proteins / metabolism
  • Middle Aged
  • Neutrophils / cytology
  • Ovarian Neoplasms / blood*
  • Ovarian Neoplasms / diagnostic imaging*
  • Ovarian Neoplasms / metabolism
  • Platelet Count
  • Preoperative Period
  • Retrospective Studies
  • Ultrasonography


  • CA-125 Antigen
  • MUC16 protein, human
  • Membrane Proteins