Update on Lupus Nephritis

Clin J Am Soc Nephrol. 2017 May 8;12(5):825-835. doi: 10.2215/CJN.05780616. Epub 2016 Nov 7.


SLE is a chronic inflammatory disease that affects the kidneys in about 50% of patients. Lupus nephritis is a major risk factor for overall morbidity and mortality in SLE, and despite potent anti-inflammatory and immunosuppressive therapies still ends in CKD or ESRD for too many patients. This review highlights recent updates in our understanding of disease epidemiology, genetics, pathogenesis, and treatment in an effort to establish a framework for lupus nephritis management that is patient-specific and oriented toward maintaining long-term kidney function in patients with lupus.

Keywords: Chronic; Discoid; Epidemiology and outcomes; Lupus Erythematosus; Renal Insufficiency; Systemic; chronic; glomerular disease; glomerulonephritis; humans; immunosuppression; kidney; kidney failure; lupus nephritis; nephritis; risk factors; systemic lupus erythematosus.

Publication types

  • Review

MeSH terms

  • Biopsy
  • Disease Progression
  • Genetic Predisposition to Disease
  • Humans
  • Kidney Failure, Chronic* / epidemiology
  • Kidney* / pathology
  • Kidney* / physiopathology
  • Lupus Nephritis* / epidemiology
  • Lupus Nephritis* / genetics
  • Lupus Nephritis* / physiopathology
  • Lupus Nephritis* / therapy
  • Phenotype
  • Predictive Value of Tests
  • Prognosis
  • Risk Factors