A microtubule dynamics reconstitutional convention

J Cell Biol. 2016 Nov 7;215(3):305-307. doi: 10.1083/jcb.201610066.


In vitro reconstitution is the fundamental test for identification of the core components of a biological process. In this issue, Moriwaki and Goshima (2016. J. Cell Biol. https://doi.org/10.1083/jcb.201604118) reconstitute all phases of microtubule dynamics through the inclusion of five key regulators and demonstrate that Polo kinase activity shifts the system from an interphase mode into an enhanced mitotic mode.

MeSH terms

  • Animals
  • Humans
  • Microtubule-Associated Proteins
  • Microtubules / metabolism*
  • Models, Biological
  • Spindle Apparatus / metabolism
  • Tubulin / metabolism


  • Microtubule-Associated Proteins
  • Tubulin