Deep analyses of the associations of a series of biomarkers with insulin resistance, metabolic syndrome, and diabetes risk in nondiabetic middle-aged and elderly individuals: results from a Chinese community-based study

Clin Interv Aging. 2016 Oct 27;11:1531-1538. doi: 10.2147/CIA.S109583. eCollection 2016.

Abstract

Objective: The current study was designed to perform deep analyses of the associations of biomarkers, including high-sensitivity C-reactive protein (hs-CRP), N-terminal prohormone of brain natriuretic peptide (NT-proBNP), and homocysteine (Hcy), with insulin resistance (IR), metabolic syndrome (MetS), and diabetes risk and evaluate the abilities of biomarkers to identify IR, MetS, and diabetes risk in Chinese community-dwelling middle-aged and elderly residents.

Participants and methods: A total of 396 participants older than 45 years underwent physical examinations and laboratory analyses following standardized protocol.

Results: Serum hs-CRP concentrations were able to identify MetS, Chinese diabetes risk score (CDRS) ≥4, high-density lipoprotein-cholesterol (HDL-c) <0.9/1.0 mmol/L, and HDL-c <1.0/1.3 mmol/L (P<0.05 for all). Serum NT-proBNP concentrations were able to identify homeostasis model assessment of IR >1.5, CDRS ≥4, overweight, and blood pressure (BP) ≥140/90 mmHg (P<0.05 for all). Serum Hcy concentrations were able to identify CDRS ≥4, general obesity, overweight, and BP ≥140/90 mmHg (P<0.05 for all). Serum hs-CRP concentrations were independently associated with MetS as well as HDL-c <1.0/1.3 mmol/L and HDL-c <0.9/1.0 mmol/L (P<0.05 for all). Serum NT-proBNP concentrations were independently associated with BP ≥140/90 mmHg (P<0.05). Serum Hcy concentrations were independently associated with CDRS ≥4 (P<0.05).

Conclusion: Serum HDL-c levels were the major determinant of the associations between serum hs-CRP levels and MetS and the key link between inflammation and MetS. There was no other association of these biomarkers with IR, MetS, and diabetes risk after full adjustment.

Keywords: biomarkers; diabetes risk; insulin resistance; metabolic syndrome; middle-aged and elderly.

MeSH terms

  • Aged
  • Asian Continental Ancestry Group
  • Biomarkers
  • C-Reactive Protein / analysis*
  • C-Reactive Protein / biosynthesis
  • China
  • Cholesterol, HDL / blood
  • Diabetes Mellitus / blood
  • Female
  • Homocysteine / biosynthesis
  • Homocysteine / blood*
  • Humans
  • Insulin Resistance*
  • Male
  • Metabolic Syndrome / blood*
  • Middle Aged
  • Natriuretic Peptide, Brain / biosynthesis
  • Natriuretic Peptide, Brain / blood*
  • Peptide Fragments / biosynthesis
  • Peptide Fragments / blood*
  • Risk

Substances

  • Biomarkers
  • Cholesterol, HDL
  • Peptide Fragments
  • pro-brain natriuretic peptide (1-76)
  • Homocysteine
  • Natriuretic Peptide, Brain
  • C-Reactive Protein