Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2016;2016:1089196.
doi: 10.1155/2016/1089196. Epub 2016 Oct 16.

Predictors of Increased Daytime Sleepiness in Patients With Chronic Obstructive Pulmonary Disease: A Cross-Sectional Study

Affiliations
Free PMC article

Predictors of Increased Daytime Sleepiness in Patients With Chronic Obstructive Pulmonary Disease: A Cross-Sectional Study

Claudia Enz et al. Sleep Disord. .
Free PMC article

Abstract

Background. Patients with Chronic Obstructive Pulmonary Disease (COPD) suffer from increased daytime sleepiness. The aim of this study was to identify potential predictors of subjective daytime sleepiness with special regard to sleep-related breathing disorder and nocturnal activity. Methods. COPD patients were recruited at the University Hospital Basel, Switzerland. COPD risk groups A-D were determined according to spirometry and COPD Assessment Test (CAT). Breathing disorder evaluation was performed with the ApneaLink device. Nocturnal energy expenditure was measured with the SenseWear Mini Armband. Subjective daytime sleepiness was recorded using the Epworth Sleepiness Scale (ESS). Results. Twenty-two patients (36%) were in COPD risk group A, 28 patients (45%) in risk group B, and 12 patients (19%) in risk groups C + D (n = 62). Eleven patients (18%) had a pathological ESS ≥ 10/24. ESS correlated positively with CAT (r = 0.386, p < 0.01) and inversely with age (r = -0.347, p < 0.01). In multiple linear regression age (β = -0.254, p < 0.05), AHI (β = 0.287, p < 0.05) and CAT score (β = 0.380, p < 0.01) were independent predictors of ESS, while nocturnal energy expenditure showed no significant association (p = 0.619). Conclusion. These findings provide evidence that daytime sleepiness in COPD patients may partly be attributable to nocturnal respiratory disturbances and it seems to mostly affect younger patients with more severe COPD symptoms.

Figures

Figure 1
Figure 1
Reasons for exclusion/nonevaluation after recruitment.

Similar articles

See all similar articles

Cited by 2 articles

References

    1. Connor J., Norton R., Ameratunga S., et al. Driver sleepiness and risk of serious injury to car occupants: population based case control study. British Medical Journal. 2002;324(7346):1125–1128. doi: 10.1136/bmj.324.7346.1125. - DOI - PMC - PubMed
    1. Slater G., Steier J. Excessive daytime sleepiness in sleep disorders. Journal of Thoracic Disease. 2012;4(6):608–616. doi: 10.3978/j.issn.2072-1439.2012.10.07. - DOI - PMC - PubMed
    1. Epstein L. J., Kristo D., Strollo P. J., Jr., et al. Clinical guideline for the evaluation, management and long-term care of obstructive sleep apnea in adults. Journal of Clinical Sleep Medicine. 2009;5(3):263–276. - PMC - PubMed
    1. Koutsourelakis I., Perraki E., Bonakis A., Vagiakis E., Roussos C., Zakynthinos S. Determinants of subjective sleepiness in suspected obstructive sleep apnoea. Journal of Sleep Research. 2008;17(4):437–443. doi: 10.1111/j.1365-2869.2008.00663.x. - DOI - PubMed
    1. McNicholas W. T. Chronic obstructive pulmonary disease and obstructive sleep apnea: overlaps in pathophysiology, systemic inflammation, and cardiovascular disease. American Journal of Respiratory and Critical Care Medicine. 2009;180(8):692–700. doi: 10.1164/rccm.200903-0347pp. - DOI - PubMed

LinkOut - more resources

Feedback