Emerging drugs and drug targets against tuberculosis

J Drug Target. 2017 Apr;25(4):296-306. doi: 10.1080/1061186X.2016.1258705. Epub 2016 Dec 2.

Abstract

Mycobacterium tuberculosis (M. tuberculosis), the causative agent of tuberculosis, uses various tactics to resist on antibiotics and evade host immunity. To control tuberculosis, antibiotics with novel mechanisms of action are urgently needed. Emerging new antibiotics and underlying novel drug targets are summarized in this paper.

Keywords: Antibiotics; Mycobacterium tuberculosis; antimicrobials resistance; drug target.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antitubercular Agents / chemistry
  • Antitubercular Agents / pharmacology
  • Antitubercular Agents / therapeutic use*
  • Cell Wall / drug effects
  • Drug Delivery Systems*
  • Electron Transport / drug effects
  • Humans
  • Mycobacterium tuberculosis / drug effects
  • Mycobacterium tuberculosis / metabolism
  • Tuberculosis / drug therapy*

Substances

  • Antitubercular Agents