High frequency of clonal IG and T-cell receptor gene rearrangements in histiocytic and dendritic cell neoplasms

Oncotarget. 2016 Nov 29;7(48):78355-78362. doi: 10.18632/oncotarget.13058.

Abstract

The 2008 World Health Organization (WHO) diagnostic criteria of histiocytic and dendritic cell neoplasms from hematopoietic and lymphoid tissues no longer required the absence of clonal B-cell/T-cell receptor gene rearrangements. It is true that the clonal B-cell/T-cell receptor gene rearrangements have been identified in rare cases of histiocytic and dendritic cell neoplasms, such as those with or following lymphoma/leukemia or in some sporadic histiocytic/dendritic cell sarcomas, but the clonal features of such group of tumor are still not clear. Here we investigated the clonal status of 33 samples including Langerhans cell histiocytosis (LCH), Langerhans cell sarcoma (LCS), follicular dendritic cell sarcoma (FDCS), interdigitating dendritic cell sarcoma (IDCS) and histiocytic sarcoma (HS). Among them, twenty-eight cases were sporadic without current or past lymphoma/leukemia. Three cases were found with a past history of T-cell lymphoma, one case was followed by extraosseous plasmacytoma, and one case was found with diffuse large B-cell lymphoma (DLBCL). Our results showed that there was a high frequency of clonal IG and T-cell receptor gene rearrangements in these cases. Notably, 4 cases of LCH and 2 cases of FDCS showed both B and T cell receptor gene rearrangements concurrently. One case of FDCS synchronous with DLBCL showed identical clonal IGH in both tumor populations and clonal TCRβ in FDCS alone. No matter if the presence of clonal receptor gene rearrangements was associated with the tumor origin or tumorigenesis, it might serve as a novel tumor marker for developing target therapy.

Keywords: Langerhans cell histiocytosis; Langerhans cell sarcoma; Pathology Section; follicular dendritic cell sarcoma; histiocytic sarcoma; interdigitating dendritic cell sarcoma.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Biomarkers, Tumor / genetics*
  • Child
  • Dendritic Cell Sarcoma, Follicular / genetics
  • Dendritic Cell Sarcoma, Follicular / immunology
  • Dendritic Cell Sarcoma, Follicular / pathology
  • Dendritic Cell Sarcoma, Interdigitating / genetics
  • Dendritic Cell Sarcoma, Interdigitating / immunology
  • Dendritic Cell Sarcoma, Interdigitating / pathology
  • Female
  • Gene Rearrangement, beta-Chain T-Cell Antigen Receptor*
  • Gene Rearrangement, gamma-Chain T-Cell Antigen Receptor*
  • Genes, Immunoglobulin Heavy Chain*
  • Genes, T-Cell Receptor beta*
  • Genes, T-Cell Receptor gamma*
  • Genetic Predisposition to Disease
  • Histiocytic Disorders, Malignant / genetics*
  • Histiocytic Disorders, Malignant / immunology
  • Histiocytic Disorders, Malignant / pathology
  • Histiocytic Sarcoma / genetics
  • Histiocytic Sarcoma / immunology
  • Histiocytic Sarcoma / pathology
  • Histiocytosis, Langerhans-Cell / genetics*
  • Histiocytosis, Langerhans-Cell / immunology
  • Histiocytosis, Langerhans-Cell / pathology
  • Humans
  • Immunoglobulin kappa-Chains / genetics*
  • Langerhans Cell Sarcoma / genetics
  • Langerhans Cell Sarcoma / immunology
  • Langerhans Cell Sarcoma / pathology
  • Male
  • Middle Aged
  • Phenotype
  • Young Adult

Substances

  • Biomarkers, Tumor
  • Immunoglobulin kappa-Chains