Lipid-membrane-incorporated arylboronate esters as agents for boron neutron capture therapy

Org Biomol Chem. 2017 Feb 21;15(7):1565-1569. doi: 10.1039/c6ob02142e. Epub 2016 Nov 8.

Abstract

Arylboronate esters bearing methyl groups in both of their ortho positions were stably incorporated into lipid membranes at high concentrations without undergoing hydrolysis to the corresponding boronic acids. This method could be used in combination with previous methods to increase the maximum ratio of boron atoms in liposomal boron carriers.

MeSH terms

  • Boron Neutron Capture Therapy*
  • Boronic Acids / chemistry*
  • Esters / chemistry*
  • Hydrolysis
  • Lipid Bilayers / chemistry*
  • Molecular Structure

Substances

  • Boronic Acids
  • Esters
  • Lipid Bilayers