Targeted therapy of multiple liver metastases after resected solitary gastric metastasis and primary pulmonary adenocarcinoma

Oncotarget. 2016 Dec 27;7(52):87479-87484. doi: 10.18632/oncotarget.13114.


Gastric metastases from lung adenocarcinoma are rare and usually asymptomatic. A 61-year-old woman was referred to our department because of a right lower pulmonary mass found on a chest X-ray film in August 2012. Right lower lobectomy was performed for pulmonary adenocarcinoma. Four months later, she developed epigastric discomfort. A fluoro-deoxy-glucose positron emission tomography/computed tomography (FDG-PET/CT) scan showed a malignancy at the cardias of the stomach. A biopsy diagnosed poorly differentiated carcinoma and a gastric carcinoma was suspected. She underwent a subtotal gastrectomy and part of esophagectomy. The histologic diagnosis was metastasis from the pulmonary adenocarcinoma. She visited us again for her increasing level of carcinoembryonic antigen (CEA) after two months. FDG-PET/CT showed multiple malignant lesions in her liver, considering metastases from pulmonary origin. As she harbored activating epidermal growth factor receptor (EGFR) mutation, she received erlotinib from April, 2013. She survives 4 years after the lung resection and is still on erotinib treatment with complete response. Although gastric metastasis from lung cancer is considered a late stage of the disease, a radical resection might provide survival in solitary metastasis. Moreover, systemic therapy was emphasized after local treatment in some late stage cases.

Keywords: gastric metastasis; liver metastases; lung cancer; surgery; targeted therapy.

Publication types

  • Case Reports

MeSH terms

  • Adenocarcinoma / pathology*
  • Adenocarcinoma of Lung
  • ErbB Receptors / genetics
  • Erlotinib Hydrochloride / therapeutic use
  • Female
  • Fluorodeoxyglucose F18
  • Gastrectomy
  • Humans
  • Liver Neoplasms / drug therapy*
  • Liver Neoplasms / secondary*
  • Lung Neoplasms / pathology*
  • Middle Aged
  • Positron Emission Tomography Computed Tomography
  • Stomach Neoplasms / secondary*
  • Stomach Neoplasms / surgery


  • Fluorodeoxyglucose F18
  • Erlotinib Hydrochloride
  • ErbB Receptors