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. 2016 Nov 10;20(1):361.
doi: 10.1186/s13054-016-1531-y.

Is the Glutamine Story Over?

Free PMC article

Is the Glutamine Story Over?

Marie Smedberg et al. Crit Care. .
Free PMC article


Glutamine has been launched as a conditionally indispensible amino acid for the critically ill. Supplementation has been recommended in guidelines from international societies. Although data have been presented pointing out that glutamine supplementation may not be for everybody, recommendations for treatments and design of study protocols have included all critically ill patients. Results from more recent studies and meta-analyses indicate that indiscriminate use of glutamine supplementation in critically ill patients may actually cause harm rather than beneficial effects. This viewpoint sorts out arguments of controversy in the glutamine story.

Keywords: Critical care; Guidelines; Hyperglutaminemia; Hypoglutaminemia.


Fig. 1
Fig. 1
Updated summary of glutamine plasma concentration as a biomarker. iv intravenous

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    1. van Zanten AR, Hofman Z, Heyland DK. Consequences of the REDOXS and METAPLUS Trials: the end of an era of glutamine and antioxidant supplementation for critically ill patients? JPEN J Parenter Enteral Nutr. 2015;39(8):890–2. doi: 10.1177/0148607114567201. - DOI - PubMed
    1. van Zanten AR, Hofman Z, Heyland DK. Authors’ response to Vermeulen et al. JPEN J Parenter Enteral Nutr. 2016;40(1):12–3. doi: 10.1177/0148607115589371. - DOI - PubMed
    1. Wernerman J. What is actually attributable to glutamine? J Parenter Enteral Nutr. 2016 (in press). - PubMed
    1. Wernerman J. How to understand the results of studies of glutamine supplementation. Crit Care. 2015;19:385. doi: 10.1186/s13054-015-1090-7. - DOI - PMC - PubMed
    1. Wilmore DW, Schloerb PR, Ziegler TR. Glutamine in the support of patients following bone marrow transplantation. Curr Opin Clin Nutr Metab Care. 1999;2(4):323–7. doi: 10.1097/00075197-199907000-00013. - DOI - PubMed