Indole Glycosides from Aqueous Fraction of Strychnos nitida

Bei Wang; Zhi Dai; Lu Liu; Xin Wei; Pei-Feng Zhu; Hao-Fei Yu; Ya-Ping Liu; Xiao-Dong Luo

doi:10.1007/s13659-016-0112-8

Indole Glycosides from Aqueous Fraction of Strychnos nitida

Nat Prod Bioprospect. 2016 Dec;6(6):285-290. doi: 10.1007/s13659-016-0112-8. Epub 2016 Nov 9.

Authors

Bei Wang^{1

2}, Zhi Dai³, Lu Liu^{1

2}, Xin Wei^{1

2}, Pei-Feng Zhu^{1

2}, Hao-Fei Yu^{1

2}, Ya-Ping Liu^{4

5}, Xiao-Dong Luo^{6

7}

Affiliations

¹ State Key Laboratory of Phytochemistry and Plant Resources in West China, Chinese Academy of Sciences, Kunming, 650201, China.
² University of Chinese Academy of Sciences, Beijing, 100049, China.
³ Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, Chinese Academy of sciences, Kunming, 650223, Yunnan, China.
⁴ State Key Laboratory of Phytochemistry and Plant Resources in West China, Chinese Academy of Sciences, Kunming, 650201, China. liuyaping@mail.kib.ac.cn.
⁵ Yunnan Key Laboratory of Natural Medicinal Chemistry, Chinese Academy of Sciences, Kunming, 650201, China. liuyaping@mail.kib.ac.cn.
⁶ State Key Laboratory of Phytochemistry and Plant Resources in West China, Chinese Academy of Sciences, Kunming, 650201, China. xdluo@mail.kib.ac.cn.
⁷ Yunnan Key Laboratory of Natural Medicinal Chemistry, Chinese Academy of Sciences, Kunming, 650201, China. xdluo@mail.kib.ac.cn.

Abstract

Three new indole glycosides 22-deoxystrictosamide (1), 22-deoxystrictosamide N ^b-oxide (2) and vincosamide 2'-O-β-D-xylopyranoside-11-O-β-D-glucopyranoside (3), together with four known analogues were isolated from aqueous fraction of Strychnos nitida. Their structures were elucidated on the basis of extensive analysis of spectroscopic data. All the alkaloids were tested for their cytotoxic activity, but they did not show any exciting result.

Keywords: Alkaloids; Indole glycosides; Strychnos nitida.