Successful Engraftment of Human Hepatocytes in uPA-SCID and FRG ® KO Mice

Methods Mol Biol. 2017;1506:117-130. doi: 10.1007/978-1-4939-6506-9_8.

Abstract

Mice with humanized chimeric liver are promising in vivo tools to evaluate the efficacy of novel compounds or vaccine induced antibodies directed against pathogens that infect the human liver. In addition they can be used to study the human-type metabolism of medicinal compounds and hepatotoxicity.

Keywords: Humanized mouse model; In vivo; Liver; Malaria; Metabolism; Plasmodium falciparum; Viral hepatitis.

MeSH terms

  • Acetoacetates / metabolism
  • Acetoacetates / toxicity
  • Animals
  • Cell Transplantation / methods*
  • Chemical and Drug Induced Liver Injury / genetics
  • Chemical and Drug Induced Liver Injury / surgery*
  • Disease Models, Animal
  • Hepatocytes / transplantation*
  • Humans
  • Hydrolases / genetics
  • Liver / cytology
  • Liver / metabolism
  • Liver / surgery
  • Mice
  • Mice, Knockout
  • Mice, SCID
  • Transplantation Chimera / genetics
  • Transplantation Chimera / physiology*
  • Urokinase-Type Plasminogen Activator / genetics

Substances

  • Acetoacetates
  • fumarylacetoacetate
  • Hydrolases
  • Urokinase-Type Plasminogen Activator
  • fumarylacetoacetase