Adhesion GPCRs as Novel Actors in Neural and Glial Cell Functions: From Synaptogenesis to Myelination

Handb Exp Pharmacol. 2016:234:275-298. doi: 10.1007/978-3-319-41523-9_12.


Adhesion G-protein-coupled receptors (aGPCRs) are emerging as key regulators of nervous system development and health. aGPCRs can regulate many aspects of neural development, including cell signaling, cell-cell and cell-matrix interactions, and, potentially, mechanosensation. Here, we specifically focus on the roles of several aGPCRs in synapse biology, dendritogenesis, and myelinating glial cell development. The lessons learned from these examples may be extrapolated to other contexts in the nervous system and beyond.

Keywords: Adhesion GPCR; Dendritogenesis; Myelination; Neurodevelopment; Synaptogenesis.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Binding Sites
  • Cell Adhesion Molecules / metabolism
  • Cell Adhesion*
  • Cell Membrane / metabolism*
  • Electrical Synapses / metabolism*
  • Humans
  • Ligands
  • Models, Molecular
  • Morphogenesis
  • Myelin Sheath / metabolism*
  • Nerve Fibers, Myelinated / metabolism*
  • Nerve Tissue Proteins / metabolism
  • Neuroglia / metabolism*
  • Neurons / metabolism*
  • Protein Binding
  • Protein Interaction Domains and Motifs
  • Receptors, G-Protein-Coupled / chemistry
  • Receptors, G-Protein-Coupled / metabolism*
  • Signal Transduction
  • Structure-Activity Relationship


  • Cell Adhesion Molecules
  • Ligands
  • Nerve Tissue Proteins
  • Receptors, G-Protein-Coupled