Prophylactic effects of sulforaphane on depression-like behavior and dendritic changes in mice after inflammation

J Nutr Biochem. 2017 Jan:39:134-144. doi: 10.1016/j.jnutbio.2016.10.004. Epub 2016 Oct 11.

Abstract

Inflammation plays a role in the pathophysiology of depression. Sulforaphane (SFN), an isothiocyanate compound derived from broccoli, is a potent activator of the NF-E2-related factor-2 (Nrf2), which plays a role in inflammation. In this study, we examined whether the prevention effects of SFN in lipopolysaccharide (LPS) induced depression-like behavior in mice. Pretreatment with SFN significantly blocked an increase in the serum tumor necrosis factor-α (TNF-α) level and an increase in microglial activation of brain regions after a single administration of LPS (0.5 mg/kg). Furthermore, SFN significantly potentiated increased serum levels of IL-10 after LPS administration. In the tail-suspension test and forced swimming test, SFN significantly attenuated an increase of the immobility time after LPS administration. In addition, SFN significantly recovered to control levels for LPS-induced alterations in the proteins such as brain-derived neurotrophic factor, postsynaptic density protein 95 and AMPA receptor 1 (GluA1) and dendritic spine density in the brain regions. Finally, dietary intake of 0.1% glucoraphanin (a glucosinolate precursor of SFN) food during the juvenile and adolescence could prevent the onset of LPS-induced depression-like behaviors and dendritic spine changes in the brain regions at adulthood. In conclusion, these findings suggest that dietary intake of SFN-rich broccoli sprout has prophylactic effects on inflammation-related depressive symptoms. Therefore, supplementation of SFN-rich broccoli sprout could be prophylactic vegetable to prevent or minimize the relapse by inflammation in the remission state of depressed patients.

Keywords: Brain-derived neurotrophic factor; Depression; Inflammation; Nrf2; Prevention; Sulforaphane; Synaptogenesis.

MeSH terms

  • Animals
  • Behavior, Animal / drug effects*
  • Brain-Derived Neurotrophic Factor / genetics
  • Brain-Derived Neurotrophic Factor / metabolism
  • Brassica / chemistry
  • Depression / chemically induced
  • Depression / drug therapy*
  • Disease Models, Animal
  • Disks Large Homolog 4 Protein / genetics
  • Disks Large Homolog 4 Protein / metabolism
  • Glucosinolates / pharmacology
  • Imidoesters / pharmacology
  • Inflammation / chemically induced
  • Inflammation / drug therapy*
  • Interleukin-10 / blood
  • Isothiocyanates / pharmacology*
  • Lipopolysaccharides / toxicity
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Oximes
  • Receptors, AMPA / genetics
  • Receptors, AMPA / metabolism
  • Sulfoxides
  • Tumor Necrosis Factor-alpha / blood

Substances

  • Brain-Derived Neurotrophic Factor
  • Disks Large Homolog 4 Protein
  • Dlg4 protein, mouse
  • Glucosinolates
  • Imidoesters
  • Isothiocyanates
  • Lipopolysaccharides
  • Oximes
  • Receptors, AMPA
  • Sulfoxides
  • Tumor Necrosis Factor-alpha
  • Interleukin-10
  • sulforaphane
  • glucoraphanin
  • glutamate receptor ionotropic, AMPA 1