Evidence Support and Guidelines for Using Heated, Humidified, High-Flow Nasal Cannulae in Neonatology: Oxford Nasal High-Flow Therapy Meeting, 2015

Clin Perinatol. 2016 Dec;43(4):693-705. doi: 10.1016/j.clp.2016.07.006.


Nasal high-flow therapy (nHFT) has become a popular form of noninvasive respiratory support in neonatal intensive care units. A meeting held in Oxford, UK, in June 2015 examined the evidence base and proposed a consensus statement. In summary, nHFT is effective for support of preterm infants following extubation. There is growing evidence evaluating its use in the primary treatment of respiratory distress. Further study is needed to assess which clinical conditions are most amenable to nHFT support, the most effective flow rates, and escalation and weaning strategies. Its suitability as first-line treatment needs to be further evaluated.

Keywords: Cannula; Nasal high-flow; Preterm; Therapy.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cannula
  • Congresses as Topic
  • Evidence-Based Medicine
  • Hot Temperature
  • Humans
  • Humidifiers
  • Infant, Newborn
  • Infant, Premature
  • Neonatology
  • Noninvasive Ventilation / methods*
  • Practice Guidelines as Topic*
  • Respiratory Distress Syndrome, Newborn / therapy*

Supplementary concepts

  • Respiratory Distress Syndrome In Premature Infants