Detection of abnormalities in febrile AIDS patients with In-111-labeled leukocyte and Ga-67 scintigraphy

Radiology. 1989 Mar;170(3 Pt 1):677-80. doi: 10.1148/radiology.170.3.2783783.


Thirty-six patients with acquired immunodeficiency syndrome (AIDS), who were febrile but without localizing signs, underwent indium-111 leukocyte scintigraphy 24 hours after injection of labeled white blood cells (WBCs) and were restudied 48 hours after injection of gallium-67 citrate. Fifty-six abnormalities were identified as possible sources of the fever; 27 were confirmed with biopsy. Of these 27, 15 were identified only on In-111 WBC scans (including colitis, sinusitis, and focal bacterial pneumonia); six, only on Ga-67 scans (predominantly Pneumocystis carinii pneumonia and lymphadenopathy); and six, on both studies (predominantly pulmonary lesions). In-111 WBC scanning revealed 21 of 27 abnormalities (78%) and gallium scanning, 12 of 27 (44%). If only one scintigraphic study has been performed, particularly with Ga-67, a significant number of lesions would not have been detected. The authors believe radionuclide evaluation of the febrile AIDS patient without localizing signs should begin with In-111 WBC scintigraphy. Gallium scanning may be used depending on results of In-111 WBC scans or if there is a high index of suspicion for P carinii pneumonia.

Publication types

  • Comparative Study

MeSH terms

  • Acquired Immunodeficiency Syndrome / complications*
  • Adult
  • Bacterial Infections / complications
  • Bacterial Infections / diagnostic imaging*
  • Citrates
  • Citric Acid
  • Colitis / complications
  • Colitis / diagnostic imaging*
  • Female
  • Fever of Unknown Origin / etiology*
  • Gallium Radioisotopes*
  • Humans
  • Indium Radioisotopes*
  • Leukocytes
  • Male
  • Middle Aged
  • Pneumonia, Pneumocystis / complications
  • Pneumonia, Pneumocystis / diagnostic imaging*
  • Radionuclide Imaging


  • Citrates
  • Gallium Radioisotopes
  • Indium Radioisotopes
  • Citric Acid