Reconsolidation and psychopathology: Moving towards reconsolidation-based treatments

Neurobiol Learn Mem. 2017 Jul;142(Pt A):162-171. doi: 10.1016/j.nlm.2016.11.005. Epub 2016 Nov 9.


Interfering with memory reconsolidation has valuable potential to be used as a treatment for maladaptive memories and psychiatric disorders. Numerous studies suggest that reconsolidation-based therapies may benefit psychiatric populations, but much remains unanswered. After reviewing the literature in clinical and healthy human populations, we discuss some of the major limitations to reconsolidation studies and clinical application. Finally, we provide recommendations for developing improved reconsolidation-based treatments, namely exploiting known boundary conditions and focusing on a novel unconditioned stimulus-retrieval paradigm.

Keywords: Addiction; Garcinol; PTSD; Psychopathology; Reconsolidation; Schizophrenia.

Publication types

  • Review

MeSH terms

  • Humans
  • Memory Consolidation / physiology*
  • Mental Disorders / psychology
  • Mental Disorders / therapy*
  • Psychotherapy / methods*