Imprecision: Limitations to Interpretation of a Large Randomized Clinical Trial
- PMID: 27840335
- PMCID: PMC5225045
- DOI: 10.1161/CIRCULATIONAHA.116.026324
Imprecision: Limitations to Interpretation of a Large Randomized Clinical Trial
Keywords: anti-inflammatory agents, non-steroidal; arthritis; celecoxib; naproxen; risk.
Comment in
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Letter by Brophy Regarding Article, "ImPRECISION: Limitations to Interpretation of a Large Randomized Clinical Trial".Circulation. 2017 May 23;135(21):e1052-e1053. doi: 10.1161/CIRCULATIONAHA.116.026414. Circulation. 2017. PMID: 28533323 No abstract available.
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References
-
- Becker MC, Wang TH, Wisniewski L, Wolski K, Libby P, Lüscher TF, Borer JS, Mascette AM, Husni ME, Solomon DH, Graham DY, Yeomans ND, Krum H, Ruschitzka F, Lincoff AM, Nissen SE, PRECISION Investigators Rationale, design, and governance of Prospective Randomized Evaluation of Celecoxib Integrated Safety versus Ibuprofen Or Naproxen (PRECISION), a cardiovascular end point trial of nonsteroidal antiinflammatory agents in patients with arthritis. Am Heart J. 2009;157:606–12. - PubMed
-
- Grosser T, Yu Y, FitzGerald GA. Emotion recollected in tranquility: lessons learned from the COX-2 saga. Annu Rev Med. 2010;61:17–33. - PubMed
-
- Coxib and traditional NSAID Trialists’ (CNT) Collaboration. Bhala N, Emberson J, Merhi A, Abramson S, Arber N, Baron JA, Bombardier C, Cannon C, Farkouh ME, FitzGerald GA, Goss P, Halls H, Hawk E, Hawkey C, Hennekens C, Hochberg M, Holland LE, Kearney PM, Laine L, Lanas A, Lance P, Laupacis A, Oates J, Patrono C, Schnitzer TJ, Solomon S, Tugwell P, Wilson K, Wittes J. Baigent C Vascular and upper gastrointestinal effects of non-steroidal anti-inflammatory drugs: meta-analyses of individual participant data from randomised trials. Lancet. 2013;382:769–79. - PMC - PubMed
-
- Couzin J. Drug testing. Massive trial of Celebrex seeks to settle safety concerns. Science. 2005;310:1890–1. - PubMed
-
- MacDonald TM, Hawkey CJ, Ford I, McMurray JJ, Scheiman JM, Hallas J, Findlay E, Grobbee DE, Hobbs FD, Ralston SH, Reid DM, Walters MR, Webster J, Ruschitzka F, Ritchie LD, Perez-Gutthann S, Connolly E, Greenlaw N, Wilson A, Wei L, Mackenzie IS. Randomized trial of switching from prescribed non-selective non-steroidal anti-inflammatory drugs to prescribed celecoxib: the Standard care vs. Celecoxib Outcome Trial (SCOT) Eur Heart J. 2016 Oct 4; pii: ehw387 [Epub ahead of print] - PMC - PubMed
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