The relationship of urocortin-2 with insulin resistance patients having PCOS

Gynecol Endocrinol. 2017 Feb;33(2):124-127. doi: 10.1080/09513590.2016.1240772. Epub 2016 Nov 12.


In this study, we aimed to compare the serum urocortin-2 (UCN2) levels in women with polycystic ovary syndrome (PCOS) and healthy women. Thirty-eight patients with PCOS and 41 healthy women were included in the study whose age and BMI matched. The fasting serum glucose, insulin, free testosterone, hs-CRP and UCN2 levels of the all participants were examined. HOMA-IR formula was used in order to calculate the insulin resistance. Circulating UCN2 levels were significantly elevated in women with PCOS compared with controls (142.93 ± 59.48 versus 98.56 ± 65.01 pg/ml, p = 0.002). FBG, serum insulin, hs-CRP and HOMA-IR levels were found to be increased in women with PCOS. There was a positive correlation between UCN2 and free-testosterone in only PCOS group (r = 0.235, p = 0.027). Multivariate logistic regression analyses revealed that the odds ratio for PCOS was 2.31 for patients in the highest quartile of UCN2 compared with those in the lowest quartile (OR = 2.31, 95% CI = 1.88-2.83, p=0.021). Multiple linear regression analysis revealed that HOMA-IR, hs-CRP and free-testosterone independently predicted UCN2 levels (p < 0.05). UCN2 levels were significantly higher in PCOS cases when compared to control group. UCN2 is thought to be effective on pathophysiology of PCOS by paracrine and autocrine pathways.

Keywords: Insulin; PCOS; urocortin-2.

MeSH terms

  • Adult
  • C-Reactive Protein / metabolism*
  • Corticotropin-Releasing Hormone / blood*
  • Female
  • Humans
  • Insulin Resistance*
  • Polycystic Ovary Syndrome / blood*
  • Testosterone / blood*
  • Urocortins / blood*
  • Young Adult


  • UCN2 protein, human
  • Urocortins
  • Testosterone
  • C-Reactive Protein
  • Corticotropin-Releasing Hormone