Ventilator-induced Lung Injury

Clin Chest Med. 2016 Dec;37(4):633-646. doi: 10.1016/j.ccm.2016.07.004. Epub 2016 Oct 14.


Prevention of ventilator-induced lung injury (VILI) can attenuate multiorgan failure and improve survival in at-risk patients. Clinically significant VILI occurs from volutrauma, barotrauma, atelectrauma, biotrauma, and shear strain. Differences in regional mechanics are important in VILI pathogenesis. Several interventions are available to protect against VILI. However, most patients at risk of lung injury do not develop VILI. VILI occurs most readily in patients with concomitant physiologic insults. VILI prevention strategies must balance risk of lung injury with untoward side effects from the preventive effort, and may be most effective when targeted to subsets of patients at increased risk.

Keywords: Acute lung injury; Acute respiratory distress syndrome; Mechanical ventilation; Respiratory mechanics; Ventilator-induced lung injury.

Publication types

  • Review

MeSH terms

  • Humans
  • Lung Injury / pathology*
  • Respiratory Distress Syndrome, Adult / therapy*
  • Respiratory Mechanics / physiology*
  • Ventilator-Induced Lung Injury*