Complete ablation of the 14-3-3epsilon protein results in multiple defects in neuropsychiatric behaviors

Behav Brain Res. 2017 Feb 15:319:31-36. doi: 10.1016/j.bbr.2016.11.016. Epub 2016 Nov 11.

Abstract

Previous studies show that mice with Ywhae deficiency show abnormalities in brain development including defects in neuronal migration of post-mitotic pyramidal neurons as well as neuronal differentiation and proliferation in neuronal progenitor cells. Also, our previous research indicated that the Ywhae knockout mice show moderate defects in working memory and anxiety-like behavior. This previous work was performed using heterozygous mutant mice. Here we performed behavioral analyses using homozygous Ywhae knockout mice and found that the homozygous Ywhae knockout mice have increased locomotor activity, decreased working memory, and increased sociability. Taken together with the results obtained from the previous pathophysiological analyses in the Ywhae knockout mice, the Ywhae knockout mouse is useful for pathophysiological analyses of neuropsychiatric disorders caused by defects during neurodevelopment.

Keywords: 14-3-3; Locomotor activity; Memory; Neurobehavior; Sociability.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • 14-3-3 Proteins / deficiency*
  • 14-3-3 Proteins / genetics
  • Analysis of Variance
  • Animals
  • Anxiety / genetics*
  • Body Weight / genetics
  • Disease Models, Animal
  • Exploratory Behavior / physiology
  • Female
  • Locomotion / genetics
  • Male
  • Memory Disorders / genetics*
  • Memory, Short-Term / physiology
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Time Factors

Substances

  • 14-3-3 Proteins