High frequency of coeliac disease in adult patients with type-I diabetes

Scand J Gastroenterol. 1989 Jan;24(1):81-4. doi: 10.3109/00365528909092243.


Anti-reticulin antibodies were measured by an indirect immunofluorescence method in 195 consecutive patients with insulin-dependent diabetes mellitus, and positive titres were found in 8 patients. A jejunal biopsy was performed in these patients, all of whom had small-intestinal atrophy. Thus the frequency of coeliac disease in adult diabetes patients was 4.1%. The patients had no signs of malabsorption or of significant abdominal complaints. We conclude that coeliac disease is commoner in type-I diabetes than in the normal population, and measurement of anti-reticulin antibodies seems to be a suitable screening method.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Antibodies, Anti-Idiotypic / analysis
  • Celiac Disease / epidemiology
  • Celiac Disease / etiology*
  • Celiac Disease / immunology
  • Diabetes Mellitus, Type 1 / complications*
  • Female
  • Finland
  • Humans
  • Intestine, Small / pathology
  • Male
  • Middle Aged
  • Reticulin / immunology


  • Antibodies, Anti-Idiotypic
  • Reticulin