An Unexpected Chink in the Transcriptional Armor of Plasmacytoid Dendritic Neoplasms

Maria Kleppe; Ross L Levine

doi:10.1016/j.ccell.2016.10.016

An Unexpected Chink in the Transcriptional Armor of Plasmacytoid Dendritic Neoplasms

Cancer Cell. 2016 Nov 14;30(5):659-660. doi: 10.1016/j.ccell.2016.10.016.

Authors

Maria Kleppe¹, Ross L Levine²

Affiliations

¹ Human Oncology and Pathogenesis Program, Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, Box 20, New York, NY 10065, USA.
² Human Oncology and Pathogenesis Program, Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, Box 20, New York, NY 10065, USA. Electronic address: leviner@mskcc.org.

PMID: 27846385
DOI: 10.1016/j.ccell.2016.10.016

Abstract

In this issue of Cancer Cell, Ceribelli et al. use functional genomic and chemical screening to reveal the existence of a TCF4/BRD4-dependent oncogenic regulatory network in blastic plasmacytoid dendritic cell neoplasm (BPDCN) and demonstrate that BPDCN cells are highly sensitive to therapeutic targeting of this novel dependency.

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MeSH terms

Dendritic Cells*
Hematologic Neoplasms / drug therapy*
Humans
Myeloproliferative Disorders
Skin Neoplasms