Sticking It to the Niche: CD98 Mediates Critical Adhesive Signals in AML

Cancer Cell. 2016 Nov 14;30(5):662-664. doi: 10.1016/j.ccell.2016.10.014.


In this issue of Cancer Cell, Bajaj and colleagues report that CD98, a heterodimeric protein highly expressed in acute myeloid leukemia (AML) and largely dispensable for basal hematopoiesis, plays an important role in facilitating leukemia stem cell adhesion to bone marrow vasculature and is a potential therapeutic target in AML.

Publication types

  • Comment

MeSH terms

  • Adhesives / metabolism*
  • Bone Marrow / metabolism
  • Bone Marrow Cells / metabolism
  • Hematopoiesis
  • Humans
  • Leukemia, Myeloid, Acute / drug therapy*


  • Adhesives