Outcomes after primary or adjuvant radiotherapy for salivary gland carcinoma

Acta Oncol. 2017 Mar;56(3):484-489. doi: 10.1080/0284186X.2016.1253863. Epub 2016 Nov 16.

Abstract

Background: We report long-term outcomes of patients treated with primary radiotherapy (RT) or surgery and adjuvant RT for salivary gland malignancies.

Materials and methods: From 1964 to 2012, 291 patients received primary RT (n = 67) or RT combined with surgery (n = 224).

Results: The 5-, 10-, and 15-year local control, local-regional control, distant metastasis-free survival, cause-specific survival and overall survival rates were 82%, 77% and 73%; 77%, 72% and 67%; 74%, 70% and 70%; 70%, 59% and 54%; and 63%, 47% and 38%, respectively. Per multivariate analysis, combined surgery and RT and T stage impacted local control; overall stage and combined surgery and RT impacted local-regional control; overall stage impacted distant metastasis-free survival; and overall stage, node positivity, clinical nerve invasion, and surgery and RT impacted cause-specific and overall survival. Five percent of patients experienced grade 3 or worse toxicity.

Conclusion: Combined surgery and RT improves local control, local-regional control, and cause-specific survival compared with primary RT for salivary tumors.

MeSH terms

  • Adenocarcinoma / mortality
  • Adenocarcinoma / radiotherapy*
  • Adenocarcinoma / surgery
  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Child
  • Combined Modality Therapy
  • Female
  • Humans
  • Male
  • Middle Aged
  • Neoadjuvant Therapy / methods*
  • Neoplasm Recurrence, Local / mortality
  • Radiotherapy, Adjuvant
  • Retrospective Studies
  • Salivary Gland Neoplasms / mortality
  • Salivary Gland Neoplasms / radiotherapy*
  • Salivary Gland Neoplasms / surgery
  • Survival Rate
  • Treatment Outcome
  • Young Adult