Clinical Implications of the Epidermal Growth Factor Receptor in the Squamous Cell Carcinoma of the Uterine Cervix

Gynecol Oncol. 1989 May;33(2):146-50. doi: 10.1016/0090-8258(89)90540-4.


The clinical implications of the epidermal growth factor (EGF) and its receptor (EGF-R) were studied in 52 squamous cell carcinomas of the uterine cervix. In comparison to 40 biopsies of the normal cervix EGF-R capacity was significantly increased in the carcinomas, while the affinity was unchanged. The amount of EGF-like substances extracted from the tumors was increased in patients with lymph node metastases, in whom 5-year survival is reduced. Irrespective of tumor stage patients with a very high level of EGF-R (greater than 100 fmole/mg protein) were more likely to have recurrences later or to die from disease: recurrence or death occurred in 5 of 7 patients with high capacity and in 2 of 45 patients with low capacity. Our data suggest that the level of EGF-R is indicative of the biological aggressiveness of cervical carcinomas.

Publication types

  • Comparative Study

MeSH terms

  • Adult
  • Carcinoma, Squamous Cell / analysis*
  • Carcinoma, Squamous Cell / mortality
  • Carcinoma, Squamous Cell / pathology
  • Cervix Uteri / analysis
  • Epidermal Growth Factor / analysis
  • ErbB Receptors / analysis*
  • Female
  • Humans
  • Lymphatic Metastasis
  • Neoplasm Metastasis
  • Neoplasm Recurrence, Local
  • Uterine Cervical Neoplasms / analysis*
  • Uterine Cervical Neoplasms / mortality
  • Uterine Cervical Neoplasms / pathology


  • Epidermal Growth Factor
  • ErbB Receptors