Effect of Erythropoietin on Postresuscitation Renal Function in a Swine Model of Ventricular Fibrillation

Biomed Res Int. 2016;2016:3567275. doi: 10.1155/2016/3567275. Epub 2016 Oct 25.


Purpose. To investigate the effect of EPO administration on postresuscitation renal function. Methods. Twenty-four female Landrace/Large-White piglets aged 10-15 weeks with average weight of 19 ± 2 kg were randomly assigned to 2 different groups of 12 subjects each. After the end of an 8-minute ventricular fibrillation, the control group (Group C) received saline as placebo, whereas the EPO group (Group E) received EPO 5000 U/kg. The animals were resuscitated according to the 2010 European Resuscitation Council Guidelines for Resuscitation. Results. Five animals (41.67%) from Group C and 11 animals (91.67%) from Group E achieved ROSC (p = 0.027). Eight animals (66.67%, 5 surviving and 3 nonsurviving) from Group C suffered severe kidney damage or AKI compared to animals from Group E, in which none of the swine had evidence of severe kidney damage or AKI (p = 0.001). There was a statistically significant difference in all tested biochemical markers between the two groups, as well as a positive correlation of creatinine with NGAL, L-FABP, and IL-18 (summed mean values' p = 0.049, 0.01, and 0.004, resp.). Conclusions. Administration of EPO protected swine from postresuscitation acute kidney injury.

MeSH terms

  • Acute Kidney Injury* / etiology
  • Acute Kidney Injury* / physiopathology
  • Acute Kidney Injury* / prevention & control
  • Animals
  • Erythropoietin / pharmacology*
  • Female
  • Kidney / pathology
  • Kidney / physiopathology*
  • Resuscitation / adverse effects*
  • Swine
  • Ventricular Fibrillation / therapy*


  • EPO protein, human
  • Erythropoietin